Genetic background influences nicotine-induced conditioned place preference and place aversion in mice.

نویسندگان

  • Yuya Ise
  • Tomohisa Mori
  • Shirou Katayama
  • Tsutomu Suzuki
  • Tzu-Chueh Wang
چکیده

This study was designed to determine whether genetic differences influence the rewarding effects of nicotine in 4 inbred strains of mice (DBA/2, BALB/c, C3H, and C57BL/6). Nicotine (subcutaneous) induced a place preference in DBA/2 and BALB/c mice but a place aversion in C57BL/6 mice. A low dose of nicotine produced a significant place preference, whereas a high dose of nicotine produced place aversion in C3H mice. These effects were completely reversed by the nicotinic receptor antagonist mecamylamine. These results strongly suggest that a conditioned state, such as rewarding effects or aversive effects, can be influenced by genetic background.

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عنوان ژورنال:
  • Journal of Nippon Medical School = Nippon Ika Daigaku zasshi

دوره 81 1  شماره 

صفحات  -

تاریخ انتشار 2014